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to protect against certain strains of the human papillomavirus (HPV), which can cause cervical, vulvar, vaginal, and anal cancers, as well as genital warts. The vaccine was first approved in 2006, and it is administered in a series of two or three shots over a six-month period. The Gardasil vaccine provides protection against the four most common HPV types that are responsible for about 70% of cervical cancer cases and 90% of genital warts cases. In 2014, a new version of the vaccine, called Gardasil 9, was approved, which offers protection against an additional five HPV types, providing even greater coverage and reducing the risk of HPV-related diseases. The vaccine works by stimulating the immune system to produce antibodies against the targeted HPV types. It is recommended for both males and females, usually starting at the age of 11 or 12, before potential exposure to HPV. However, Gardasil can be administered to individuals up to the age of 45. Gardasil has been extensively studied, and its safety and efficacy have been established through clinical trials involving thousands of participants. Common side effects of the vaccine include pain, redness, or swelling at the injection site, as well as headaches, fever, and nausea. Serious adverse events are rare, and the vaccine is generally well-tolerated. The introduction of Gardasil has had a significant impact on reducing HPV-related diseases and improving public health. Studies have shown a substantial decrease in the prevalence of HPV infections, genital warts, and precancerous cervical lesions since the vaccine's introduction. Gardasil has been recommended by various health organizations, including the World Health Organization, the Centers for Disease Control and Prevention, and national immunization programs worldwide. However, the vaccine has not been without controversy. Some concerns have been raised about its long-term safety, as well as potential adverse effects. Additionally, there have been debates regarding the mandatory vaccination of young girls and the role of the pharmaceutical industry in promoting the vaccine. Overall, the Gardasil Wikipedia page provides detailed information about the vaccine, its development, mechanism of action, recommended dosage, safety profile, and impact on public health. It also covers controversies, criticisms, and ongoing research to further improve HPV prevention and control.