Array ( [0] => {{Short description|Genus of fungi}} [1] => {{pp-pc1}} [2] => {{technical|date=August 2018}} [3] => {{Automatic taxobox [4] => | image = Penicillium Pengo.jpg [5] => | image_caption = ''Penicillium'' sp. [6] => | taxon = Penicillium [7] => | authority = [[Johann Heinrich Friedrich Link|Link]] (1809) [8] => | type_species = ''[[Penicillium expansum]]'' [9] => | type_species_authority = Link (1809) [10] => | subdivision_ranks = Species [11] => | subdivision = [[List of Penicillium species|over 300]] [12] => | synonyms_ref = Page ''Penicillium'' on {{cite web | url=https://www.mycobank.org/page/Name%20details%20page/39268 | title=Mycobank | publisher=[[Westerdijk Fungal Biodiversity Institute]] | access-date=2023-09-20}} [13] => | synonyms = {{Collapsible list|bullets=on [14] => |''Aspergillopsis'' Sopp (1912) [15] => |''Carpenteles'' Langeron (1922) [16] => |''Chromocleista'' Yaguchi & Udagawa (1993) [17] => |''Citromyces'' Wehmer (1893) [18] => |''Coremium'' Link (1809) [19] => |''Eladia'' G. Sm. (1961) [20] => |''Eupenicillium'' F. Ludw. (1892) [21] => |''Floccaria'' [[Grev.]] (1827)
[22] => |''Hemicarpenteles'' A. K. Sarbhoy & Elphick (1968) [23] => |''Moniliger'' Letell. (1839) [24] => |''Pritzeliella'' [[Henn.]] (1903) [25] => |''Thysanophora'' W.B. Kendr. (1961) [26] => |''Toluromyces'' Delitsch (1943) [27] => |''Walzia'' [[Nikolai Vasilyevich Sorokin|Sorokin]] (1871) [28] => }} [29] => }} [30] => [31] => '''''Penicillium''''' ({{IPAc-en|ˌ|p|ɛ|n|ɪ|ˈ|s|ɪ|l|i|əm}}) is a [[genus]] of [[Ascomycota|ascomycetous]] [[fungus|fungi]] that is part of the [[mycobiome]] of many species and is of major importance in the natural environment, in food spoilage, and in food and drug production. [32] => [33] => Some members of the genus produce [[penicillin]], a molecule that is used as an [[antibiotic]], which kills or stops the growth of certain kinds of bacteria. Other species are used in [[cheesemaking]]. According to the ''Dictionary of the Fungi'' (10th edition, 2008), the widespread genus contains over 300 species. [34] => [35] => ==Taxonomy== [36] => The genus was first described in the scientific literature by [[Johann Heinrich Friedrich Link]] in his 1809 work ''Observationes in ordines plantarum naturales''; he wrote, "''Penicillium. Thallus e floccis caespitosis septatis simplicibus aut ramosis fertilibus erectis apice penicillatis''", where ''penicillatis'' means "having tufts of fine hair".Identification and nomenclature of the genus Penicillium, C.M. Visagie1, J. Houbraken1, , , J.C. Frisvad2, , , S.-B. Hong3, C.H.W. Klaassen4, G. Perrone5, K.A. Seifert6, J. Varga7, T. Yaguchi8, R.A. Samson, 22 September 2014, https://dx.doi.org/10.1016/j.simyco.2014.09.001 Link included three species—''[[Penicillium candidum|P. candidum]]'', ''[[Penicillium expansum|P. expansum]]'', and ''[[Penicillium glaucum|P. glaucum]]''—all of which produced a brush-like [[conidiophore]] (asexual spore-producing structure). The common apple rot fungus ''P. expansum'' was later selected as the [[type species]]. [37] => [38] => In his 1979 [[monograph]], John I. Pitt divided ''Penicillium'' into four [[subgenera]] based on conidiophore [[morphology (biology)|morphology]] and branching pattern: ''Aspergilloides'', ''Biverticillium'', ''Furcatum'', and ''Penicillium''. Species included in subgenus ''Biverticillium'' were later merged into ''[[Talaromyces]]''. [39] => [40] => === Species === [41] => {{Main|List of Penicillium species}} [42] => [[File:Ascomycetes.jpg|thumb|right|Various fungi including ''Penicillium'' and ''Aspergillus'' species growing in [[axenic culture]]]] [43] => [[File:Penicilliummandarijntjes.jpg|thumb|right|Some penicillium mold on [[mandarin orange]]s, probably ''Penicillium digitatum''.]] [44] => [45] => Selected species include; [46] => * ''[[Penicillium albocoremium]]'' [47] => * ''[[Penicillium aurantiogriseum]]'', a grain contaminant [48] => * ''[[Penicillium bilaiae]]'', which is an agricultural inoculant [49] => * ''[[Penicillium camemberti]]'', which is used in the production of [[Camembert (cheese)|Camembert]], [[Brie cheese|Brie]] and [[Cambozola]] [[cheese]]s [50] => * ''[[Penicillium candidum]]'', which is used in making Brie and Camembert. It has been reduced to synonymy with ''Penicillium camemberti'' [51] => * ''[[Penicillium chrysogenum]]'' (previously known as ''[[Penicillium notatum]]''), which produces the [[antibiotic]] [[penicillin]] [52] => * ''[[Penicillium claviforme]]'' [53] => * ''[[Penicillium commune]]'' [54] => * ''[[Penicillium crustosum]]'' [55] => * ''[[Penicillium digitatum]]'', a ''Citrus'' pathogen [56] => * ''[[Penicillium echinulatum]]'' produces [[Mycophenolic acid]] [57] => * ''[[Penicillium expansum]]'', a pathogen of apples and other fruit, produces [[patulin]] [58] => * ''[[Penicillium glabrum]]'' [59] => * ''[[Penicillium imranianum]]'' [60] => * ''[[Penicillium italicum]]'', a ''Citrus'' pathogen [61] => * ''[[Penicillium lacussarmientei]]'' [62] => * ''[[Penicillium lusitanum]]'', isolated from marine habitat [63] => * ''[[Penicillium purpurogenum]]'' [64] => * ''[[Penicillium roqueforti]]'', which is used in making [[Roquefort cheese|Roquefort]], [[Danish Blue cheese]], English Blue [[Stilton cheese]], [[Gorgonzola cheese]], and [[Cambozola]] [65] => * ''[[Penicillium stoloniferum]]'' [66] => * ''[[Penicillium ulaiense]]'', a ''Citrus'' pathogen in Asia [67] => * ''[[Penicillium verrucosum]]'', a grain contaminant which produces [[ochratoxin A]] [68] => * ''[[Penicillium viridicatum]]'' [69] => [70] => === Etymology === [71] => The genus name is derived from the [[Latin]] root ''penicillum'', meaning "painter's brush", and refers to the chains of conidia that resemble a broom. [72] => [73] => == Characteristics == [74] => [[File:Penicillium Spp..jpg|thumb|''Penicillium'' sp. under bright field microscopy (10 × 100 magnification) with lactophenol cotton blue stain]] [75] => [76] => The [[thallus]] ([[mycelium]]) consists of highly branched networks of [[multinucleated]], usually colourless [[hyphae]], with each pair of cells separated by a [[septum]]. [[Conidiophores]] are at the end of each branch accompanied by green spherical constricted units called [[conidia]]. These propagules play a significant role in reproduction; conidia are the main dispersal strategy of these fungi.{{Cite journal|last=Pitt|first=J.|date=1985|title=A laboratory guide to common Penicillium species| volume=79 |page=491 | doi=10.2307/3807483|jstor=3807483|s2cid=84610634}} [77] => [78] => Sexual reproduction involves the production of [[ascospore]]s, commencing with the fusion of an [[archegonium]] and an [[antheridium]], with sharing of nuclei. The irregularly distributed [[ascus|asci]] contain eight unicellular ascospores each. [79] => [80] => == Ecology == [81] => Species of ''Penicillium'' are ubiquitous soil fungi preferring cool and moderate climates, commonly present wherever organic material is available. [[Saprophytic]] species of ''Penicillium'' and ''[[Aspergillus]]'' are among the best-known representatives of the [[Eurotiales]] and live mainly on organic biodegradable substances. Commonly known in America as [[Mold (fungus)|mold]]s, they are among the main causes of [[food spoilage]], especially species of [[subgenus]] ''Penicillium''. Many species produce highly toxic [[mycotoxin]]s. The ability of these ''Penicillium'' species to grow on seeds and other stored foods depends on their propensity to thrive in low humidity and to colonize rapidly by aerial dispersion while the seeds are sufficiently moist. Some species have a blue color, commonly growing on old bread and giving it a blue fuzzy texture. [82] => [83] => Some ''Penicillium'' species affect the fruits and bulbs of plants, including ''[[Penicillium expansum|P. expansum]]'', apples and pears; ''[[Penicillium digitatum|P. digitatum]]'', citrus fruits; and ''[[Penicillium allii|P. allii]]'', garlic. Some species are known to be pathogenic to animals; ''[[Penicillium corylophilum|P. corylophilum]]'', ''[[Penicillium fellutanum|P. fellutanum]]'', ''[[Penicillium implicatum|P. implicatum]]'', ''[[Penicillium janthinellum|P. janthinellum]]'', ''[[Penicillium viridicatum|P. viridicatum]]'', and ''[[Penicillium waksmanii|P. waksmanii]]'' are potential pathogens of [[mosquitoes]]. [84] => [85] => ''Penicillium'' species are present in the air and dust of indoor environments, such as homes and public buildings. The fungus can be readily transported from the outdoors, and grow indoors using building material or accumulated soil to obtain nutrients for growth. ''Penicillium'' growth can still occur indoors even if the relative humidity is low, as long as there is sufficient moisture available on a given surface. A British study determined that ''Aspergillus''- and ''Penicillium''-type spores were the most prevalent in the indoor air of residential properties, and exceeded outdoor levels. Even [[Tile#Ceiling tiles|ceiling tile]]s can support the growth of ''Penicillium''—as one study demonstrated—if the [[relative humidity]] is 85% and the moisture content of the tiles is greater than 2.2%. [86] => [87] => Some ''Penicillium'' species cause damage to machinery and the combustible materials and lubricants used to run and maintain them. For example, ''[[Penicillium chrysogenum|P. chrysogenum]] (formerly [[P. chrysogenum|P. notatum]])'', ''[[Penicillium steckii|P. steckii]]'', ''[[Penicillium notatum| ]][[Penicillium cyclopium|P. cyclopium]]'', and ''[[Penicillium nalgiovensis|P. nalgiovensis]]'' affect fuels; ''P. chrysogenum'', ''[[Penicillium rubrum|P. rubrum]]'', and ''[[Penicillium verrucosum|P. verrucosum]]'' cause damage to oils and lubricants; ''[[Penicillium regulosum|P. regulosum]]'' damages optical and protective glass. [88] => [89] => == Economic value == [90] => {{multiple image [91] => | align = right [92] => | direction = vertical [93] => | width = 200 [94] => | image1 = Penicillin core.svg [95] => | caption1 = Core structure of penicillin [96] => | image2 = Griseofulvin.svg [97] => | caption2 = Griseofulvin [98] => }} [99] => Several species of the genus ''Penicillium'' play a central role in the production of cheese and of various meat products. To be specific, ''Penicillium'' molds are found in [[blue cheese]]. ''[[Penicillium camemberti]]'' and ''[[Penicillium roqueforti]]'' are the molds on [[Camembert]], [[Brie]], [[Roquefort]], and many other cheeses. ''[[Penicillium nalgiovense]]'' is used in soft mold-ripened cheeses, such as Nalžovy (ellischau) cheese, and to improve the taste of sausages and hams, and to prevent colonization by other molds and bacteria. [100] => [101] => In addition to their importance in the food industry, species of ''Penicillium'' and ''Aspergillus'' serve in the production of a number of biotechnologically produced [[enzyme]]s and other macromolecules, such as [[gluconic acid|gluconic]], [[citric acid|citric]], and [[tartaric acid]]s, as well as several [[pectinase]]s, [[lipase]], [[amylase]]s, [[cellulase]]s, and [[protease]]s. Some ''Penicillium'' species have shown potential for use in [[bioremediation]], more specifically [[mycoremediation]], because of their ability to break down a variety of [[Environmental xenobiotic|xenobiotic compounds]]. [102] => [103] => The genus includes a wide variety of species molds that are the source molds of major [[antibiotic]]s. [[Penicillin]], a drug produced by ''[[Penicillium chrysogenum|P. chrysogenum]] (formerly P. notatum),'' was accidentally discovered by [[Alexander Fleming]] in 1929, and found to inhibit the growth of [[Gram-positive]] bacteria (see [[beta-lactams]]). Its potential as an antibiotic was realized in the late 1930s, and [[Howard Florey]] and [[Ernst Chain]] purified and concentrated the compound. The drug's success in saving soldiers in World War II who had been dying from infected wounds resulted in Fleming, Florey and Chain jointly winning the [[Nobel Prize in Medicine]] in 1945. [104] => [105] => [[Griseofulvin]] is an [[antifungal drug]] and a potential [[chemotherapeutic agent]] that was discovered in ''[[Penicillium griseofulvum|P. griseofulvum]]''. Additional species that produce compounds capable of inhibiting the growth of tumor cells ''[[in vitro]]'' include: ''[[Penicillium pinophilum|P. pinophilum]]'', ''[[Penicillium canescens|P. canescens]]'', and ''[[Penicillium glabrum|P. glabrum]]''. [106] => [107] => ==Reproduction== [108] => Although many [[eukaryote]]s are able to reproduce [[Sexual reproduction|sexually]], as much as 20% of [[fungus|fungal]] species had been thought to reproduce exclusively by [[Asexual reproduction|asexual]] means. However recent studies have revealed that [[sex]] occurs even in some of the supposedly asexual species. For example, sexual capability was recently shown for the fungus ''[[Penicillium roqueforti]]'', used as a starter for [[blue cheese]] production.{{cite journal |vauthors=Ropars J, Dupont J, Fontanillas E, Rodríguez de la Vega RC, Malagnac F, Coton M, Giraud T, López-Villavicencio M |title=Sex in cheese: evidence for sexuality in the fungus Penicillium roqueforti |journal=PLOS ONE |volume=7 |issue=11 |pages=e49665 |year=2012 |pmid=23185400 |pmc=3504111 |doi=10.1371/journal.pone.0049665 |bibcode=2012PLoSO...749665R |doi-access=free }} This finding was based, in part, on evidence for functional [[mating type]] (MAT) genes that are involved in fungal sexual compatibility, and the presence in the sequenced genome of most of the important genes known to be involved in [[meiosis]]. ''[[Penicillium chrysogenum]]'' is of major medical and historical importance as the original and present-day industrial source of the antibiotic penicillin. The species was considered asexual for more than 100 years despite concerted efforts to induce sexual reproduction. However, in 2013, Bohm et al.{{cite journal |vauthors=Böhm J, Hoff B, O'Gorman CM, Wolfers S, Klix V, Binger D, Zadra I, Kürnsteiner H, Pöggeler S, Dyer PS, Kück U |title=Sexual reproduction and mating-type-mediated strain development in the penicillin-producing fungus Penicillium chrysogenum |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=110 |issue=4 |pages=1476–81 |date=January 2013 |pmid=23307807 |pmc=3557024 |doi=10.1073/pnas.1217943110 |doi-access=free }} finally demonstrated sexual reproduction in ''P. chrysogenum''. [109] => [110] => These findings with ''Penicillium'' species are consistent with accumulating evidence from studies of other [[Eukaryote|eukaryotic]] species that sex was likely present in the common ancestor of all [[eukaryote]]s.{{cite journal |vauthors=Malik SB, Pightling AW, Stefaniak LM, Schurko AM, Logsdon JM |title=An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis |journal=PLOS ONE |volume=3 |issue=8 |pages=e2879 |year=2008 |pmid=18663385 |pmc=2488364 |doi=10.1371/journal.pone.0002879 |bibcode=2008PLoSO...3.2879M |doi-access=free }} Furthermore, these recent results suggest that sex can be maintained even when very little [[genetic variability]] is produced. [111] => [112] => Prior to 2013, when the "[[Teleomorph, anamorph and holomorph#One fungus, one name|one fungus, one name]]" nomenclature change came into effect, ''Penicillium'' was used as the genus for anamorph (clonal forms) of fungi and ''Talaromyces'' was used for the teleomorph (sexual forms) of fungi. After 2013 however, fungi were reclassified based on their genetic relatedness to each other and now the genera ''Penicillium'' and ''Talaromyces'' both contain some species capable of only clonal reproduction and others that can reproduce sexually. 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W. |title=A Text-Book of Mycology and Plant Pathology |url=https://archive.org/details/atextbookmycolo00harsgoog |location=London |publisher=Churchill Livinstone |year=1917 |oclc=879097707}} [162] => [163] => == External links == [164] => {{Sister project links|d=Q843136|c=category:Penicillium|n=no|wikt=yes|b=no|v=no|voy=no|s=no|m=no|mw=no|q=no|species=yes}} [165] => [166] => * {{cite journal |last=Asan |first=A. |year=2004 |title=''Aspergillus'', ''Penicillium'', and Related Species Reported from Turkey |journal=Mycotaxon |volume=89 |issue=1 |pages=155–7 |url=http://www.mycotaxon.com/resources/checklists/asan-v89-checklist.pdf }} [167] => * {{cite book |url=https://books.google.com/books?id=3KJewsIL5vQC&q=genus+penicillium&pg=PA66 |last1=Samson |first1=R.A. |first2=J.I. |last2=Pitt |title=Integration of Modern Taxonomic Methods For Penicillium and Aspergillus Classification |isbn=978-9058231598 |publisher=CRC Press |year=2000 |page=66 }} [168] => [169] => {{Taxonbar|from=Q843136}} [170] => {{Authority control}} [171] => [172] => [[Category:Penicillium| ]] [173] => [[Category:Medicinal fungi]] [174] => [[Category:Taxa named by Johann Heinrich Friedrich Link]] [175] => [[Category:Taxa described in 1809]] [176] => [[Category:Eurotiomycetes genera]] [] => )
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Penicillium

Penicillium is a genus of moulds that consists of over 350 different species. It is a common fungus found worldwide in soil, decaying organic matter, and as a natural contaminant in various foods.

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It is a common fungus found worldwide in soil, decaying organic matter, and as a natural contaminant in various foods. One of the most well-known species within this genus is Penicillium chrysogenum, which played a vital role in the discovery of the antibiotic penicillin. Penicillium species have a characteristic blue-green or yellow-green color and produce asexual spores called conidia. They are typically filamentous and can grow on a wide range of substrates, including fruits, cheese, bread, and other organic materials. Some species are also known to cause spoilage in various agricultural products. Penicillium has both beneficial and harmful effects on humans and the environment. On one hand, it is used extensively in the food industry for its role in cheese and meat production, as well as in the production of various enzymes and organic acids. On the other hand, it can produce mycotoxins, which are toxic secondary metabolites that can contaminate crops and result in health issues if consumed. In addition to its industrial uses, Penicillium has had a significant impact in the field of medicine. The discovery of penicillin by Sir Alexander Fleming in 1928 revolutionized the treatment of bacterial infections and led to the development of numerous other antibiotics. Penicillium fungi are still widely used in the commercial production of these antibiotics. Overall, the genus Penicillium is an important group of fungi that have significant economic and medical implications. Its diverse species have both positive and negative effects, making it a subject of interest in various scientific fields, such as microbiology, mycology, and pharmacology.

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