João Pedro de Magalhães

Fascinating study, showing that cancer cells secrete antioxidants that suppress immunity. When I started in the longevity field, the free radical theory was dominant. Antioxidants were touted as anti-aging. We were among the first to criticize the free radical theory of https://t.co/SOJujOZjYn #CancerResearch #Antioxidants #Longevity #Nospecificcountriesarementionedinthetweet.

Evolution has already run the greatest experiment in longevity. Species are a vast set of natural interventions on the rate of ageing, with huge untapped potential. The challenge now is to uncover how the genome determines how long a species lives. https://t.co/kwvPATCDpU #Evolution #Longevity #Genomics #Nospecificcountriesarementionedinthetweet.

GLP-1 drugs significantly extend lifespan in female mice when given late in life 👀 Semaglutide (Ozempic) also improved physiological function, suggesting it might mimic the effects of caloric restriction. https://t.co/ZSui5qjODd #GLP1 #Semaglutide #LifespanResearch #Therearenospecificcountrycodesrelevanttothistweet.

Epigenetic age ≠ biological age A reminder that epigenetic clocks are interesting and promising tools, but their biology is poorly understood and they have plenty of limitations. For instance, epigenetic age increases with pregnancy and COVID-19, so just because an epigenetic #Epigenetics #BiologicalAge #HealthScience #Therearenospecificcountrycodesmentionedinthetweet.

I've always found it baffling that the US, the world's wealthiest country, has such a low life expectancy (currently 54th in the world). The US actually spends more per person on healthcare than any country on earth, and still has a life expectancy ~4 years below other wealthy https://t.co/yvEWbbMwtX #HealthCare #LifeExpectancy #USWealth #US

Novo Nordisk's clinical trial for Ziltivekimab, an antibody targeting pro-inflammatory cytokine IL-6, failed 👀 Interestingly, both IL-6 and hsCRP fell with treatment, suggesting an anti-inflammatory effect, yet this did not translate into fewer cardiovascular events. https://t.co/jSZTM1Qxad #NovoNordisk #Ziltivekimab #ClinicalTrials #Nospecificcountriesarementionedinthetweet.

This tragic case is a reminder of why clinical trials and risk-averse regulatory agencies matter. And why unregulated "anti-aging" treatments should concern us all. What the longevity field needs is more rigorous science, not more hype. #ClinicalTrials #AntiAging #LongevityResearch #Therearenospecificcountrymentionsinthetweet #sotherearenocountrycodestoreturn.

Aging is not primarily driven by molecular damage or the hallmarks, but instead result from developmental programs that run on beyond their adaptive purpose, gradually reducing cell proliferation, plasticity, and tissue regeneration. #Aging #CellBiology #TissueRegeneration #Nospecificcountrycodes.

Wait, what!? This conflates anti-wrinkle creams with treating dementia. But it highlights the challenge in ageing science. How can we convince the world that targeting the ageing process (the key driver of dementia, frailty, and so much suffering) is the right thing to do? #AgeingScience #DementiaResearch #HealthyAging #Nospecificcountrycodescanbeidentifiedinthetweet.

Sad but often true. Incentives matter, and although many scientists want to discover the truth, the funding system is generally designed to reward risk-averse, incremental and fashionable research instead of ambitious, high-risk ideas. #IncentivesMatter #ResearchFunding #ScienceInnovation #Nospecificcountrycodesfound.

Social insects are an excellent example of how the genome regulates lifespan 🐜 In Harpegnathos ants, when a queen dies, some workers undergo a caste switch to reproductive pseudo-queens and live up to 5× longer 🤯 Now a new study identifies a specific peptide (HCRG1) that #SocialInsects #AntQueen #LifespanResearch #Thetweetdoesnotmentionanyspecificcountries.Therefore #therearenocountrycodestoreturn.

Regular reminder that changes in aging biomarkers do not mean the aging process has changed. Lifestyle can modulate health and biomarkers, but health is not the same as becoming biologically younger or older. Be sceptical of headlines claiming they’ve "changed biological age". #Aging #Biomarkers #HealthAwareness #Nospecificcountrycodesfound.

Impressive study suggesting that hyperglycosylation (addition of sugars to proteins) may be a driver of Alzheimer’s disease 👀 They also show that glucosamine supplements (often used for joint health) are associated with Alzheimer’s progression and mortality. #Alzheimers #HealthResearch #Glucosamine #Therearenospecificcountriesmentionedinthetweet.

AI is not trained in biology, it is trained on human interpretations of biology. As such, it carries our biases, knowledge gaps, and misunderstandings. Great to discuss the impact of AI in biology and geroscience in beautiful Coimbra @UnivdeCoimbra https://t.co/y1Fg5Sk90K #AI #Biology #Geroscience #PT

New paper on gene therapies in longevity and aging 🧬 Gene therapies have enormous potential to treat age-related diseases, target aging and extend lifespan. We discuss recent advances and remaining challenges in gene therapies for aging, highlighting promising targets, https://t.co/3hnwhyQoCm #GeneTherapy #Longevity #AgingResearch #Nospecificcountrycodesarementionedinthetweet.

Can we use machine learning to predict longevity drugs? 💊 In our updated preprint led by @AlekseyVBelikov we trained ML models on compounds in the DrugAge database that extend lifespan in mice. Features associated with longevity drugs included receptors for neurotransmitters, #MachineLearning #Longevity #DrugDiscovery #Therearenospecificcountryreferencesinthetweetprovided.Therefore #therearenocountrycodestoreturn.

Impressive study linking epigenetic changes to accelerated ageing in mice and humans 🧬 Patients and mice with gain-of-function mutations in a DNA methylation enzyme (DNMT3A) exhibit features of accelerated ageing. Moreover, region-specific DNA hypermethylation leads to stem #Epigenetics #Aging #Research #Therearenospecificcountriesmentionedinthetweetprovided.Therefore #theresponseis: