Epigenetic age ≠ biological age A reminder that epigenetic clocks are interesting and promising tools, but their biology is poorly understood and they have plenty of limitations. For instance, epigenetic age increases with pregnancy and COVID-19, so just because an epigenetic #Epigenetics #BiologicalAge #HealthScience #Therearenospecificcountrycodesmentionedinthetweet.
The CDC (and the CDC Foundation) ran multiple campaigns encouraging COVID-19 vaccination during pregnancy, with a particular focus on Black and Hispanic women because uptake was consistently lower in those groups. Two of the most relevant efforts were: Pregnant & Protected** #COVID19 #Vaccination #Pregnancy #US
The Climate Threat To Pregnancy Is Here — Health Systems Aren’t Ready 🚨 Extreme heat & air pollution are raising the risk of miscarriage, stillbirth & premature birth. Yet pregnant women are still missing from much of the world's climate & health policy. https://t.co/ltv84mrlLC #ClimateCrisis #PregnancyHealth #WomenInPolicy #Nospecificcountrycodesarementionedinthetweet.
@vanranstmarc Als je heel precies kijkt naar wat er op 23 april 2021 beschikbaar was, is er een belangrijk onderscheid dat in de Nederlandse communicatie gemakkelijk verloren ging: er was niet één onderzoek onder 90.000 zwangere vrouwen waaruit was gebleken dat vaccinatie veilig en effectief was. Die circa 90.000 was vooral een Amerikaans real-worldaantal gevaccineerde zwangere vrouwen bij wie op dat moment geen duidelijk veiligheidssignaal was gemeld. De daadwerkelijk gepubliceerde Amerikaanse veiligheidsanalyse was veel kleiner en had een zeer korte follow-up. Dat maakt de onderbouwing van met name de veiligheid voor miskramen en andere zwangerschapsuitkomsten in april 2021 aanzienlijk zwakker dan het getal 90.000 doet vermoeden. Wat Nederland op 23 april letterlijk als reden gaf De Federatie Medisch Specialisten meldde namens de multidisciplinaire werkgroep COVID-19 & Zwangerschap: inmiddels waren in de VS ongeveer 90.000 zwangere vrouwen met Pfizer of Moderna gevaccineerd zonder noemenswaardige bijwerkingen; “Vanaf nu wordt daarom aan alle zwangere vrouwen geadviseerd om zich te laten vaccineren.” Het Britse JCVI had een week eerder vrijwel dezelfde redenering gebruikt: ongeveer 90.000 Amerikaanse zwangeren waren gevaccineerd, voornamelijk met Pfizer en Moderna, en er waren geen veiligheidsproblemen naar voren gekomen. Maar “90.000 vaccinaties zonder safety concern” is epidemiologisch iets anders dan een studie onder 90.000 zwangeren die aantoont dat het vaccin veilig is. Het beste Amerikaanse onderzoek van dat moment omvatte geen 90.000 vrouwen Op 21 april 2021, twee dagen vóór het Nederlandse advies, publiceerde CDC-onderzoeker Tom Shimabukuro met collega’s de beroemde studie in The New England Journal of Medicine. Zij gebruikten drie Amerikaanse surveillancesystemen: v-safe, het specifieke v-safe pregnancy registry en VAERS. De cijfers waren: Groep Aantal v-safe-deelnemers die aangaven zwanger te zijn 35.691 Ingeschreven in specifiek pregnancy registry 3.958 Zwangerschap al beëindigd op de peildatum 827 Levende geboorten 712 Pregnancy losses 115 Spontane abortussen/miskramen 104 Dus van de ongeveer 90.000 zwangere gevaccineerden waarop beleidsmakers wezen, hadden de onderzoekers voor zwangerschapsuitkomsten slechts 3.958 vrouwen in het specifieke register, en bij slechts 827 was de zwangerschap überhaupt al beëindigd. Dat is het eerste grote probleem. Nog belangrijker: 700 van die 827 waren pas in het derde trimester gevaccineerd Dit is naar mijn oordeel de cruciale methodologische beperking. Later bevestigden de onderzoekers dat van de 827 vrouwen met een afgeronde zwangerschap maar liefst 700 hun eerste relevante vaccindosis in het derde trimester hadden gekregen. Dat heeft een enorme consequentie. Een vrouw die bijvoorbeeld bij 34 weken wordt gevaccineerd en twee weken later een gezond kind krijgt, levert wel informatie op over acute bijwerkingen en eventueel zeer late zwangerschapsproblemen. Maar zij kan vrijwel niets vertellen over: •miskraam in week 8; •miskraam in week 12; •een effect op de embryonale ontwikkeling in het eerste trimester; •aangeboren afwijkingen veroorzaakt tijdens organogenese; •effecten van vaccinatie gedurende het grootste deel van de zwangerschap. Zij was immers al door die risicoperiode heen voordat ze werd gevaccineerd. Het getal van 12,6% miskramen zag er geruststellender uit dan methodologisch gerechtvaardigd was In het oorspronkelijke artikel stond dat van de 827 voltooide zwangerschappen 104 eindigden in een spontane abortus, oftewel: 104 / 827 = 12,6%. Dat percentage leek mooi binnen het gebruikelijke achtergrondpercentage van miskramen te vallen. Maar 827 is niet de juiste noemer om het miskraamrisico na vroege vaccinatie te berekenen. Waarom niet? Omdat die 700 vrouwen die pas in het derde trimester waren gevaccineerd onmogelijk na hun vaccinatie nog een miskraam vóór 20 weken konden krijgen. Omdat die 700 vrouwen pas in het derde trimester waren gevaccineerd. #COVID19 #Vaccinatie #Zwangerschap
Bret Weinstein said something that won’t leave my head: For the first time in 300,000 years of human evolution, we removed the cost from the single biggest reward nature ever invented — sex and pair-bonding. Reliable birth control + abortion = you can now cash the evolutionary lottery ticket without paying the 20-year mortgage of pregnancy, diapers, sleepless nights, and college funds. Result? An entire generation of 18–35-year-olds walking around with the energy, libido, hormones, and protective instincts that evolution spent millions of years calibrating for child-rearing… but with zero actual children. That energy didn’t disappear. It got redirected. Heather Heying’s observation is brutal: young women especially began treating ideologies the exact way evolution wired them to treat babies. Climate change, social justice, whatever the cause of the month is — it gets defended with literal mama-bear ferocity, the same neurochemistry that once guarded a toddler from predators now guards an abstract idea from wrong think. And now Elon is promising the second shoe is about to drop: AI-driven abundance will make money as “free” as sex became in the 1970s. Both of evolution’s primary carrots — mating and resource acquisition suddenly cost almost nothing. Weinstein’s ice-cold question: When producing and protecting actual children is no longer the central organizing principle of adult life… and when creating wealth is no longer required for status, security, or attracting a mate…What is left to give a human life direction, meaning, and structure? https://x.com/Bitcoin_Teddy/status/2077512782430486720
🩷💙 Parents who have experienced pregnancy loss before 24 weeks can now apply for a Baby Loss Certificate. This important scheme provides recognition for bereaved parents & the heartbreak they have endured. Credit to Sinn Féin Minister John O’Dowd, baby loss organisations & https://t.co/XpGmI265gi #BabyLoss #PregnancyLoss #BereavementSupport #IE
Anne Hathaway is pregnant with her third child with Adam Shulman – The sweet way she announced it. (translated)
Sinn Féin’s legislation to remove the mandatory three-day waiting period for abortion care in early pregnancy has passed. This is an important step forward for women’s healthcare and one of the most significant changes since we voted to repeal the 8th amendment. Women, https://t.co/tOjMbqiEzj #AbortionRights #WomensHealth #SinnFein #IE
Sice jsme si s Danem řekli, že to oznámíme spolu, ale Dan to už vyzradil. Ano, je to tak. Čekáme s Danem miminko a Dan je v pátém měsíci. Bude to holčička a bude se jmenovat Daniela. 🍼👶 https://t.co/UM87JBM6u5 #pregnancy #babyannouncement #family
Women who trialed the newly-launched OdonAssist, an innovative inflatable birth device invented by a car mechanic, praised it as a much-needed alternative to outdated methods like forceps and ventouse, claiming it provided a gentler and less invasive experience during childbirth. #ChildbirthInnovation #PregnancyCare #BirthRevolution #AR #GB #ZA
Maria Patzwald, diagnosed with pre-eclampsia during her second pregnancy, participated in a pioneering trial aimed at treating the condition by targeting a specific protein, which successfully extended her pregnancy by ten days, significantly improving her baby’s chances of survival at birth. #Pregnancy #PreEclampsia #MaternalHealth #US #DE #GB
Maria Patzwald, a 38-year-old expectant mother diagnosed with severe preeclampsia, participated in a pioneering trial that targeted a specific protein believed to be responsible for the condition, resulting in the safe extension of her pregnancy by ten days and a healthier delivery for her son, highlighting the potential of new treatments to address the root causes of preeclampsia and improve maternal and newborn outcomes. #Pregnancy #Health #Research #US #DE #GB
Maria Patzwald, a 38-year-old woman diagnosed with severe preeclampsia during her second pregnancy, participated in a pioneering clinical trial that targeted a specific protein believed to cause the condition, leading to a significant extension of her pregnancy by 10 days and an increased survival chance for her premature son. #Pregnancy #Preeclampsia #MedicalResearch #US #DE #GB
Maria Patzwald, a 38-year-old mother, participated in a pioneering trial aimed at treating preeclampsia—which affects many pregnancies and poses serious risks—by targeting a specific protein in the blood, leading to a successful extension of her pregnancy by two weeks and improving the chances of survival for her premature son. #Pregnancy #HealthInnovation #PreEclampsia #US #DE #GB
Maria Patzwald, a 38-year-old woman, shares her experience of being part of a pioneering clinical trial aimed at treating preeclampsia, a potentially fatal pregnancy complication, which helped extend her pregnancy by ten days, leading to the safe birth of her son at 34 weeks, significantly improving his chances of survival. #PregnancyHealth #PreEclampsia #MaternalCare #US #DE #GB
Maria Patzwald credits a groundbreaking trial that targeted a protein believed to cause preeclampsia for helping her son be born at 34 weeks, potentially improving outcomes for premature infants and offering new hope for treatment options in managing the condition that affects thousands of mothers and babies globally each year. #Pregnancy #Healthcare #Innovation #US #DE #GB
Maria Patzwald, a 38-year-old woman diagnosed with preeclampsia during her second pregnancy, participated in a pioneering trial aimed at treating the condition by targeting a specific protein, which led to her son being born at 34 weeks, significantly increasing his chances of survival. #Pregnancy #Healthcare #PreEclampsia #US #DE #GB
A 38-year-old woman named Maria Patzwald participated in a pioneering trial aimed at treating preeclampsia, a potentially fatal pregnancy complication, and her involvement helped extend her son's gestation by two weeks, significantly improving his chances of survival. #PregnancyCare #MedicalResearch #PreEclampsia #US #DE #GB
Maria Patzwald, a 38-year-old pregnant woman diagnosed with severe preeclampsia, participated in a pioneering trial aimed at treating the condition, which affects maternal and neonatal health, and was able to have her son born at 34 weeks, significantly improving his chances of survival. #PregnancyHealth #PreEclampsia #MaternalHealth #US #DE #GB
Maria Patzwald, a 38-year-old pregnant woman diagnosed with severe preeclampsia, participated in a pioneering trial aimed at treating the condition, which affects maternal and neonatal health, and was able to have her son born at 34 weeks, significantly improving his chances of survival. #PregnancyHealth #PreEclampsia #MaternalHealth #US #DE #GB
