Array ( [0] => {{Short description|Study of microscopic organisms}} [1] => [[File:Agar plate with colonies.jpg|thumb|right|An [[agar plate]] streaked with [[microorganism]]s]] [2] => {{TopicTOC-Biology}} [3] => [4] => '''Microbiology''' ({{etymology|grc|''{{wikt-lang|grc|μῑκρος}}'' ({{grc-transl|μῑκρος}})|small||''{{wikt-lang|grc|βίος}}'' ({{grc-transl|βίος}})|[[life]]||''{{wikt-lang|grc|-λογία}}'' ({{grc-transl|[[-logy|-λογία]]}})|study of}}) is the [[branches of science|scientific study]] of [[microorganisms]], those being of [[unicellular organism|unicellular]] (single-celled), [[multicellular organism|multicellular]] (consisting of complex cells), or [[non-cellular life|acellular]] (lacking cells).{{cite web |url=https://www.nature.com/subjects/microbiology |title=Microbiology |website=[[Nature (journal)|Nature]] |publisher=[[Nature Portfolio]] (of [[Springer Nature]]) |access-date=2020-02-01}}{{cite book | veditors = Madigan M, Martinko J |title=Brock Biology of Microorganisms |edition=13th |publisher=[[Pearson Education]] |year=2006 |isbn=978-0-321-73551-5 |page=1096}} Microbiology encompasses numerous sub-disciplines including [[virology]], [[bacteriology]], [[protistology]], [[mycology]], [[immunology]], and [[parasitology]]. [5] => [6] => [[eukaryote|Eukaryotic]] microorganisms possess membrane-bound [[organelle]]s and include [[fungi]] and [[protists]], whereas [[prokaryote|prokaryotic]] organisms—all of which are microorganisms—are conventionally classified as lacking membrane-bound organelles and include [[Bacteria]] and [[Archaea]].{{Cite book|title=Bergey's Manual of Systematics of Archaea and Bacteria| vauthors = Whitman WB |publisher=John Wiley and Sons|year=2015|isbn=9781118960608|doi=10.1002/9781118960608|citeseerx = 10.1.1.737.4970| veditors = Whitman WB, Rainey F, Kämpfer P, Trujillo M, Chun J, Devos P, Hedlund B, Dedysh S }}{{cite journal | vauthors = Pace NR | title = Time for a change | language = En | journal = Nature | volume = 441 | issue = 7091 | pages = 289 | date = May 2006 | pmid = 16710401 | doi = 10.1038/441289a | s2cid = 4431143 | bibcode = 2006Natur.441..289P | doi-access = free }} [[Microbiologist]]s traditionally relied on culture, staining, and [[microscopy]] for the isolation and identification of microorganisms. However, less than 1% of the microorganisms present in common environments can be cultured in isolation using current means.{{cite journal |vauthors=Amann RI, Ludwig W, Schleifer KH | title = Phylogenetic identification and in situ detection of individual microbial cells without cultivation | journal = Microbiological Reviews | volume = 59 | issue = 1 | pages = 143–169 | date = March 1995 | pmid = 7535888 | pmc = 239358 | doi = 10.1128/mr.59.1.143-169.1995 }} With the emergence of [[biotechnology]], Microbiologists currently rely on [[molecular biology]] tools such as DNA sequence-based identification, for example, the [[16S ribosomal RNA|16S rRNA]] gene sequence used for bacterial identification. [7] => [8] => [[Virus]]es have been variably classified as organisms,{{cite web | vauthors = Rice G | title = Are Viruses Alive? | url = http://serc.carleton.edu/microbelife/yellowstone/viruslive.html | date = 2007-03-27 |access-date = 2007-07-23}} as they have been considered either as very simple microorganisms or very complex molecules. [[Prions]], never considered as microorganisms, have been investigated by virologists, however, as the clinical effects traced to them were originally presumed due to chronic viral infections, virologists took a search—discovering "infectious proteins". [9] => [10] => The existence of microorganisms was predicted many centuries before they were first observed, for example by the [[Jainism|Jains]] in India and by [[Marcus Terentius Varro]] in ancient Rome. The first recorded microscope observation was of the fruiting bodies of moulds, by [[Robert Hooke]] in 1666, but the Jesuit priest [[Athanasius Kircher]] was likely the first to see microbes, which he mentioned observing in milk and putrid material in 1658. [[Antonie van Leeuwenhoek]] is considered a [[List of people considered father or mother of a scientific field|father of microbiology]] as he observed and experimented with [[microscopic organisms]] in the 1670s, using simple [[microscope]]s of his design. Scientific microbiology developed in the 19th century through the work of [[Louis Pasteur]] and in medical microbiology [[Robert Koch]]. [11] => [12] => ==History== [13] => {{More information|List of microbiologists#Proto-microbiologists|l1=Proto-microbiologists|History of microscopy|Microscopic discovery of bacteria}} [14] => [15] => [[File:Avicenna TajikistanP17-20Somoni-1999 (cropped).png|left|thumb|upright|[[Avicenna]] postulated the existence of microorganisms.]] [16] => The existence of microorganisms was hypothesized for many centuries before their actual discovery. The existence of unseen microbiological life was postulated by [[Jainism]] which is based on [[Mahavira]]'s teachings as early as 6th century BCE (599 BC - 527 BC).{{cite book | vauthors = Dundas P | veditors = Hinnels J | title = The Jain | publisher =Routledge | year = 2002 | location = London | isbn =978-0-415-26606-2 }}{{rp|24}} [[Paul Dundas]] notes that Mahavira asserted the existence of unseen microbiological creatures living in earth, water, air and fire.{{rp|88}} [[Jain scriptures]] describe [[nigoda]]s which are sub-microscopic creatures living in large clusters and having a very short life, said to pervade every part of the universe, even in tissues of plants and flesh of animals.{{cite book | vauthors = Jaini P | title =The Jaina Path of Purification | publisher =Motilal Banarsidass | year =1998 | location =New Delhi | isbn =978-81-208-1578-0 |page= 109}} The [[Ancient Rome|Roman]] [[Marcus Terentius Varro]] made references to microbes when he warned against locating a homestead in the vicinity of swamps "because there are bred certain minute creatures which cannot be seen by the eyes, which float in the air and enter the body through the mouth and nose and thereby cause serious diseases."{{cite book | vauthors = Varro MT | author-link1 = Marcus Terentius Varro | title = The three books of M. Terentius Varro concerning agriculture. | publisher = At the University Press | location = Charing Cross, London | date = 1800 | volume = 1 | page = xii }} [17] => [18] => [[Persians|Persian]] scientists hypothesized the existence of microorganisms, such as [[Avicenna]] in his book ''[[The Canon of Medicine]]'', [[Ibn Zuhr]] (also known as Avenzoar) who discovered [[scabies]] mites, and [[Muhammad ibn Zakariya al-Razi|Al-Razi]] who gave the earliest known description of [[smallpox]] in his book ''The Virtuous Life'' (al-Hawi).{{cite web|title=فى الحضارة الإسلامية - ديوان العرب|trans-title=Microbiology in Islam|url=http://www.diwanalarab.com/spip.php?article34512|work=Diwanalarab.com|language=ar|access-date=14 April 2017}} The tenth-century [[Taoist]] {{em|Baoshengjing}} describes "countless micro organic worms" which resemble vegetable seeds, which prompted Dutch sinologist [[Kristofer Schipper]] to claim that "the existence of harmful bacteria was known to the Chinese of the time."{{cite journal | last=Huang | first=Shih-Shan Susan | title=Daoist Imagery of Body and Cosmos, Part 2: Body Worms and Internal Alchemy | journal=Journal of Daoist Studies | volume=4 | issue=1 | date=2011 | issn=1941-5524 | doi=10.1353/dao.2011.0001 | pages=32–62| s2cid=57857037 }} [19] => [20] => In 1546, [[Girolamo Fracastoro]] proposed that [[epidemic]] [[diseases]] were caused by transferable seedlike entities that could transmit infection by direct or indirect contact, or vehicle transmission.{{cite book | vauthors = Fracastoro G | orig-date = 1546 | title = De Contagione et Contagiosis Morbis | trans-title = On Contagion and Contagious Diseases | language = Latin | translator = Wright WC | translator-link = Wilmer Cave Wright | date = 1930 | location = New York | publisher = G.P. Putnam }} [21] => [22] => [[File:Anthonie van Leeuwenhoek (1632-1723). Natuurkundige te Delft Rijksmuseum SK-A-957.jpeg|thumb|upright|[[Antonie van Leeuwenhoek]] (1632–1723)]] [23] => [[File:Statue of Robert Koch in Berlin.jpg|thumb|Statue of [[Robert Koch]], one of the founders of microbiology,{{cite web | url=https://www.rki.de/EN/Content/Institute/History/Robert_Koch_en.html | title=RKI - Robert Koch - Robert Koch: One of the founders of microbiology }} in Berlin]] [24] => [[File:Martinus Willem Beijerinck in his laboratory.jpg|thumb|upright|[[Martinus Beijerinck]] is often considered as a [[history of virology|founder of virology]].]] [25] => [26] => In 1676, [[Antonie van Leeuwenhoek]], who lived most of his life in [[Delft]], Netherlands, observed [[bacteria]] and other microorganisms using a [[Antonie van Leeuwenhoek#Techniques and discoveries|single-lens microscope of his own design]].{{cite journal | vauthors = Lane N | title = The unseen world: reflections on Leeuwenhoek (1677) 'Concerning little animals' | journal = Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences | volume = 370 | issue = 1666 | page = 20140344 | date = April 2015 | pmid = 25750239 | pmc = 4360124 | doi = 10.1098/rstb.2014.0344 | author-link = Nick Lane }} He is considered a [[List of people considered father or mother of a scientific field|father of microbiology]] as he used simple single-lensed [[microscope]]s of his own design. While Van Leeuwenhoek is often cited as the first to observe microbes, [[Robert Hooke]] made his first recorded microscopic observation, of the fruiting bodies of [[Mold (fungus)|mould]]s, in 1665.{{cite journal | vauthors = Gest H | title = The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world | journal = Perspectives in Biology and Medicine | volume = 48 | issue = 2 | pages = 266–272 | year = 2005 | pmid = 15834198 | doi = 10.1353/pbm.2005.0053 | s2cid = 23998841 }} It has, however, been suggested that a Jesuit priest called [[Athanasius Kircher]] was the first to observe microorganisms.{{cite book | vauthors = Wainwright M |title=An Alternative View of the Early History of Microbiology |volume=52 |pages=333–55 |year=2003 |pmid=12964250 |doi=10.1016/S0065-2164(03)01013-X |series=Advances in Applied Microbiology |isbn=978-0-12-002654-8 }} [27] => [28] => Kircher was among the first to design magic lanterns for projection purposes, and so he was well acquainted with the properties of lenses. He wrote "Concerning the wonderful structure of things in nature, investigated by Microscope" in 1646, stating "who would believe that vinegar and milk abound with an innumerable multitude of worms." He also noted that putrid material is full of innumerable creeping animalcules. He published his ''Scrutinium Pestis'' (Examination of the Plague) in 1658, stating correctly that the disease was caused by microbes, though what he saw was most likely red or white blood cells rather than the plague agent itself. [29] => [30] => ==The birth of bacteriology== [31] => [32] => [[File:Albert Edelfelt - Louis Pasteur - 1885.jpg|thumb|left|upright|Innovative [[laboratory glassware]] and experimental methods developed by [[Louis Pasteur]] and other biologists contributed to the young field of bacteriology in the late 19th century.]] [33] => [34] => The field of [[bacteriology]] (later a subdiscipline of microbiology) was founded in the 19th century by [[Ferdinand Cohn]], a botanist whose studies on [[algae]] and [[Phototroph|photosynthetic bacteria]] led him to describe several bacteria including ''[[Bacillus]]'' and ''[[Beggiatoa]]''. Cohn was also the first to formulate a scheme for the [[taxonomic classification]] of bacteria, and to discover [[endospore]]s.{{cite journal | vauthors = Drews G |title=Ferdinand Cohn, among the Founder of Microbiology |journal=ASM News |volume=65 |issue=8 |page=547 |year=1999}} [[Louis Pasteur]] and [[Robert Koch]] were contemporaries of Cohn, and are often considered to be the fathers of modern microbiology and [[medical microbiology]], respectively.{{cite book | veditors = Ryan KJ, Ray CG | title=Sherris Medical Microbiology | edition=4th | publisher=McGraw Hill | year=2004 | isbn=978-0-8385-8529-0 }} Pasteur is most famous for his series of experiments designed to disprove the then widely held [[theory of spontaneous generation]], thereby solidifying microbiology's identity as a biological science.{{cite journal | vauthors = Bordenave G | title = Louis Pasteur (1822-1895) | journal = Microbes and Infection | volume = 5 | issue = 6 | pages = 553–560 | date = May 2003 | pmid = 12758285 | doi = 10.1016/S1286-4579(03)00075-3 }} One of his students, Adrien Certes, is considered the founder of marine microbiology.{{cite journal | vauthors = Adler A, Dücker E | title = When Pasteurian Science Went to Sea: The Birth of Marine Microbiology | journal = Journal of the History of Biology | volume = 51 | issue = 1 | pages = 107–133 | date = March 2018 | pmid = 28382585 | doi = 10.1007/s10739-017-9477-8 | s2cid = 22211340 }} Pasteur also designed methods for [[food preservation]] ([[pasteurization]]) and vaccines against several diseases such as [[anthrax]], fowl cholera and [[rabies]]. Koch is best known for his contributions to the [[germ theory of disease]], proving that specific diseases were caused by specific pathogenic microorganisms. He developed a series of criteria that have become known as the [[Koch's postulates]]. Koch was one of the first [[scientists]] to focus on the isolation of [[bacteria]] in [[pure culture]] resulting in his description of several novel bacteria including ''[[Mycobacterium tuberculosis]]'', the causative agent of [[tuberculosis]]. [35] => [36] => While Pasteur and Koch are often considered the founders of microbiology, their work did not accurately reflect the true diversity of the microbial world because of their exclusive focus on microorganisms having direct medical relevance. It was not until the late 19th century and the work of [[Martinus Beijerinck]] and [[Sergei Winogradsky]] that the true breadth of microbiology was revealed. Beijerinck made two major contributions to microbiology: the discovery of [[virus]]es and the development of [[enrichment culture]] techniques.{{cite web | vauthors = Johnson J | title=Martinus Willem Beijerinck | work=APSnet| publisher=American Phytopathological Society | url=http://apsnet.org/education/feature/TMV/intro.html | archive-url=https://web.archive.org/web/20100620173433/http://apsnet.org/education/feature/TMV/intro.html | archive-date=2010-06-20 | year=2001 |orig-year=1998 | access-date=May 2, 2010}} Retrieved from Internet Archive January 12, 2014. While his work on the [[tobacco mosaic virus]] established the basic principles of virology, it was his development of enrichment culturing that had the most immediate impact on microbiology by allowing for the cultivation of a wide range of microbes with wildly different physiologies. Winogradsky was the first to develop the concept of [[chemolithotrophy]] and to thereby reveal the essential role played by microorganisms in geochemical processes.{{cite book |vauthors=Paustian T, Roberts G | chapter=Beijerinck and Winogradsky Initiate the Field of Environmental Microbiology | title=Through the Microscope: A Look at All Things Small | at=§ 1–14 | edition=3rd | year=2009 | publisher=Textbook Consortia | chapter-url=http://www.microbiologytext.com/index.php?module=Book&func=displayarticle&art_id=32}} He was responsible for the first isolation and description of both [[nitrifying bacteria|nitrifying]] and [[nitrogen-fixing bacteria]]. French-Canadian microbiologist [[Felix d'Herelle]] co-discovered [[bacteriophage]]s in 1917 and was one of the earliest applied microbiologists.{{cite journal | vauthors = Keen EC | title = Felix d'Herelle and our microbial future | journal = Future Microbiology | volume = 7 | issue = 12 | pages = 1337–1339 | date = December 2012 | pmid = 23231482 | doi = 10.2217/fmb.12.115 }} [37] => [38] => [[Joseph Lister, 1st Baron Lister|Joseph Lister]] was the first to use [[phenol]] disinfectant on the open wounds of patients.{{cite journal | vauthors = Lister BJ | title = The classic: On the antiseptic principle in the practice of surgery. 1867 | journal = Clinical Orthopaedics and Related Research | volume = 468 | issue = 8 | pages = 2012–2016 | date = August 2010 | pmid = 20361283 | pmc = 2895849 | doi = 10.1007/s11999-010-1320-x }} [39] => [40] => ==Branches== [41] => [[File:LUA, Faculty of Food Technology Food microbiology laboratory.jpg|thumb|A university food microbiology laboratory]] [42] => {{main|Branches of microbiology}} [43] => [44] => The [[branches of microbiology]] can be classified into applied sciences, or divided according to taxonomy, as is the case with [[bacteriology]], [[mycology]], [[protozoology]], [[virology]], [[phycology]], and [[microbial ecology]]. There is considerable overlap between the specific branches of microbiology with each other and with other disciplines, and certain aspects of these branches can extend beyond the traditional scope of microbiology{{Cite news |url=http://www.generalmicroscience.com/microbiology/branches-of-microbiology/ |title=Branches of Microbiology |date=2017-01-13 |work=General MicroScience |access-date=2017-12-10}}{{cite book |title=Brock Biology of Microorganisms |isbn=978-0321897398 |edition=14th| vauthors = Madigan MT, Martinko JM, Bender KS, Buckley DH, Stahl DA |year=2015 |publisher=Pearson }} A pure research branch of microbiology is termed [[cellular microbiology]]. [45] => [46] => ==Applications== [47] => [48] => While some people have [[Mysophobia|fear of microbes]] due to the association of some microbes with various human diseases, many microbes are also responsible for numerous beneficial processes such as [[industrial fermentation]] (e.g. the production of [[Ethanol|alcohol]], [[vinegar]] and [[dairy products]]), [[antibiotic]] production and act as molecular vehicles to transfer DNA to complex organisms such as plants and animals. Scientists have also exploited their knowledge of microbes to produce biotechnologically important [[enzyme]]s such as [[Taq polymerase]],{{Cite book| vauthors = Gelfand DH |chapter=Taq DNA Polymerase|date=1989|work=PCR Technology: Principles and Applications for DNA Amplification|pages=17–22| veditors = Erlich HA |publisher=Palgrave Macmillan UK|language=en|doi=10.1007/978-1-349-20235-5_2|isbn=978-1-349-20235-5|title=PCR Technology|s2cid=100860897 }} [[reporter gene]]s for use in other genetic systems and novel molecular biology techniques such as the [[two-hybrid screening|yeast two-hybrid system]].{{Cite journal |last=Uetz |first=Peter |date=December 2012 |title=Editorial for "The Yeast two-hybrid system" |url=https://pubmed.ncbi.nlm.nih.gov/23317557/ |journal=Methods |volume=58 |issue=4 |pages=315–316 |doi=10.1016/j.ymeth.2013.01.001 |issn=1095-9130 |pmid=23317557}} [49] => [50] => Bacteria can be used for the industrial production of [[amino acid]]s. [[organic acids]], [[vitamin]], [[proteins]], [[antibiotics]] and other commerically used metabolites with are produced by microorganisms. ''[[Corynebacterium glutamicum]]'' is one of the most important bacterial species with an annual production of more than two million tons of amino acids, mainly L-glutamate and L-lysine.{{cite book | veditors = Burkovski A | title = Corynebacteria: Genomics and Molecular Biology | publisher = Caister Academic Press | year = 2008 | url=http://www.horizonpress.com/cory | isbn =978-1-904455-30-1 | access-date = 2016-03-25}} Since some bacteria have the ability to synthesize antibiotics, they are used for medicinal purposes, such as ''[[Streptomyces]]'' to make [[aminoglycoside antibiotics]].{{cite journal | vauthors = Fourmy D, Recht MI, Blanchard SC, Puglisi JD | title = Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic | journal = Science | volume = 274 | issue = 5291 | pages = 1367–1371 | date = November 1996 | pmid = 8910275 | doi = 10.1126/science.274.5291.1367 | s2cid = 21602792 | bibcode = 1996Sci...274.1367F }} [51] => [52] => [[File:Cuves de fermentations.jpg|thumb|upright|left|Fermenting tanks with [[yeast]] being used to [[Brewing|brew]] [[beer]] ]] [53] => [54] => A variety of [[biopolymer]]s, such as [[polysaccharide]]s, [[polyester]]s, and [[polyamide]]s, are produced by microorganisms. Microorganisms are used for the biotechnological production of biopolymers with tailored properties suitable for high-value medical application such as [[tissue engineering]] and drug delivery. Microorganisms are for example used for the biosynthesis of [[xanthan]], [[alginate]], [[cellulose]], [[cyanophycin]], poly(gamma-glutamic acid), [[levan polysaccharide|levan]], [[hyaluronic acid]], organic acids, [[oligosaccharide]]s [[polysaccharide]] and polyhydroxyalkanoates.{{cite book | veditors = Rehm BH | title = Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives | publisher = Caister Academic Press | year = 2008 | url=http://www.horizonpress.com/biopolymers | isbn =978-1-904455-36-3 | access-date = 2016-03-25}} [55] => [56] => Microorganisms are beneficial for [[microbial biodegradation]] or [[bioremediation]] of domestic, agricultural and industrial wastes and subsurface [[pollution]] in soils, sediments and marine environments. The ability of each microorganism to degrade [[toxic waste]] depends on the nature of each [[contaminant]]. Since sites typically have multiple pollutant types, the most effective approach to [[microbial biodegradation]] is to use a mixture of bacterial and fungal species and strains, each specific to the [[biodegradation]] of one or more types of contaminants.{{cite book | veditors = Diaz E | title = Microbial Biodegradation: Genomics and Molecular Biology | edition = 1st | publisher = Caister Academic Press | year = 2008 | url = https://archive.org/details/microbialbiodegr0000unse | isbn = 978-1-904455-17-2 | access-date = 2016-03-25 | url-access = registration }} [57] => [58] => [[Mutualism (biology)|Symbiotic]] microbial communities confer benefits to their human and animal hosts health including aiding digestion, producing beneficial vitamins and amino acids, and suppressing pathogenic microbes. Some benefit may be conferred by eating fermented foods, [[probiotics]] (bacteria potentially beneficial to the digestive system) or [[prebiotics]] (substances consumed to promote the growth of probiotic microorganisms).{{cite journal | vauthors = Macfarlane GT, Cummings JH | title = Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? | journal = BMJ | volume = 318 | issue = 7189 | pages = 999–1003 | date = April 1999 | pmid = 10195977 | pmc = 1115424 | doi = 10.1136/bmj.318.7189.999 }}{{cite book | veditors = Tannock GW | title = Probiotics and Prebiotics: Scientific Aspects | publisher = Caister Academic Press | year = 2005 | url=http://www.horizonpress.com/pro3 | isbn =978-1-904455-01-1 | access-date = 2016-03-25}} The ways the microbiome influences human and animal health, as well as methods to influence the microbiome are active areas of research.{{cite magazine|url=http://www.scientificamerican.com/article.cfm?id=strange-but-true-humans-carry-more-bacterial-cells-than-human-ones|title=Humans Carry More Bacterial Cells than Human Ones| vauthors = Wenner M |magazine= Scientific American|date=30 November 2007|access-date=14 April 2017}} [59] => [60] => Research has suggested that microorganisms could be useful in the treatment of [[cancer]]. Various strains of non-pathogenic [[Clostridium|clostridia]] can infiltrate and replicate within solid [[tumors]]. Clostridial vectors can be safely administered and their potential to deliver therapeutic proteins has been demonstrated in a variety of preclinical models.{{cite book | vauthors = Mengesha A, Dubois L, Paesmans K, Wouters B, Lambin P, Theys J |year=2009|chapter=Clostridia in Anti-tumor Therapy | veditors = Brüggemann H, Gottschalk G |title=Clostridia: Molecular Biology in the Post-genomic Era|publisher=Caister Academic Press|isbn = 978-1-904455-38-7 }} [61] => [62] => Some bacteria are used to study fundamental mechanisms. An example of model bacteria used to study [[motility]]{{cite journal | vauthors = Zusman DR, Scott AE, Yang Z, Kirby JR | title = Chemosensory pathways, motility and development in Myxococcus xanthus | journal = Nature Reviews. Microbiology | volume = 5 | issue = 11 | pages = 862–872 | date = November 2007 | pmid = 17922045 | doi = 10.1038/nrmicro1770 | s2cid = 2340386 }} or the production of polysaccharides and development is ''[[Myxococcus xanthus]]''.{{cite journal | vauthors = Islam ST, Vergara Alvarez I, Saïdi F, Guiseppi A, Vinogradov E, Sharma G, Espinosa L, Morrone C, Brasseur G, Guillemot JF, Benarouche A, Bridot JL, Ravicoularamin G, Cagna A, Gauthier C, Singer M, Fierobe HP, Mignot T, Mauriello EM | display-authors = 6 | title = Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion | journal = PLOS Biology | volume = 18 | issue = 6 | pages = e3000728 | date = June 2020 | pmid = 32516311 | pmc = 7310880 | doi = 10.1371/journal.pbio.3000728 | doi-access = free }} [63] => [64] => [65] => == See also == [66] => {{colbegin}} [67] => * [[Biosafety]] [68] => * ''[[Microbes and Man]]'' [69] => ;Professional organizations [70] => * [[American Society for Microbiology]] [71] => * [[Federation of European Microbiological Societies]] [72] => * [[Society for Applied Microbiology]] [73] => * [[Society for General Microbiology]] [74] => ;Journals [75] => * [[Critical Reviews in Microbiology]] [76] => * [[International Journal of Systematic and Evolutionary Microbiology]] [77] => * [[Journal of Bacteriology]] [78] => * [[Nature Reviews Microbiology]] [79] => {{colend}} [80] => {{Portal bar|Biology}} [81] => [82] => == References == [83] => {{Reflist|30em}} [84] => [85] => == Further reading == [86] => {{refbegin}} [87] => * {{cite journal | vauthors = Kreft JU, Plugge CM, Grimm V, Prats C, Leveau JH, Banitz T, Baines S, Clark J, Ros A, Klapper I, Topping CJ, Field AJ, Schuler A, Litchman E, Hellweger FL | display-authors = 6 | title = Mighty small: Observing and modeling individual microbes becomes big science | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 110 | issue = 45 | pages = 18027–18028 | date = November 2013 | pmid = 24194530 | pmc = 3831448 | doi = 10.1073/pnas.1317472110 | bibcode = 2013PNAS..11018027K | doi-access = free }} [88] => * {{Cite book| vauthors = Madigan MT, Martinko JM, Bender KS, Buckley DH, Stahl DA |url= https://books.google.com/books?id=eBnLCQAAQBAJ |title=Brock Biology of Microorganisms, Global Edition |date=2015-06-05|publisher=Pearson Education Limited|isbn=978-1-292-06831-2}} [89] => {{refend}} [90] => [91] => == External links == [92] => {{Wikisource portal|Microbiology}} [93] => {{WVD}} [94] => {{Library resources box [95] => |by=no [96] => |onlinebooks=no [97] => |others=no [98] => |about=yes [99] => |label=Microbiology}} [100] => * {{Commons category-inline}} [101] => * {{Wikiquote-inline}} [102] => * nature.com [http://www.nature.com/subjects/microbiology Latest Research, reviews and news on microbiology] [103] => * [http://www.microbes.info/ Microbes.info] is a microbiology information portal containing a vast collection of resources including articles, news, frequently asked questions, and links pertaining to the field of microbiology. [104] => * {{In Our Time|Microbiology|b007753d|Microbiology}} [105] => * [http://www.microbiologybook.org/book/welcome.htm Immunology, Bacteriology, Virology, Parasitology, Mycology and Infectious Disease] [106] => * [http://arjournals.annualreviews.org/loi/micro/ Annual Review of Microbiology] {{Webarchive|url=https://web.archive.org/web/20090120021246/http://arjournals.annualreviews.org/loi/micro |date=2009-01-20 }} [107] => [108] => {{Biology-footer}} [109] => {{Bacteria}} [110] => {{Fungus}} [111] => {{Protozoa protist}} [112] => {{Virus topics}} [113] => {{microorganisms}} [114] => {{Authority control}} [115] => [116] => [[Category:Microbiology| ]] [117] => [[Category:Branches of biology]] [118] => [[Category:Microscopy]] [] => )
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Microbiology

Microbiology is the scientific study of microorganisms, which are tiny, single-celled organisms that cannot be seen with the naked eye. This field of study encompasses the study of microorganisms such as bacteria, archaea, fungi, viruses, and other microscopic organisms.

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This field of study encompasses the study of microorganisms such as bacteria, archaea, fungi, viruses, and other microscopic organisms. Microorganisms play a significant role in various aspects of life, including human health, the environment, and industrial applications. The history of microbiology dates back to the mid-17th century when pioneers like Antonie van Leeuwenhoek discovered the existence of microorganisms through the use of microscopes. Since then, microbiologists have made significant advancements in understanding the structure, function, and behavior of microorganisms. Microbiology is a broad field of study that includes various sub-disciplines such as bacteriology, virology, mycology, parasitology, and immunology. Microbiologists employ various techniques and methodologies to study microorganisms, including culturing them in laboratory settings, investigating their genetics and molecular biology, and studying their interactions with other organisms and their environment. The knowledge gained from microbiology research has had profound impacts in various areas. In medicine, it has led to the development of antibiotics and vaccines, contributing to the prevention and treatment of various diseases. Microbiology has also played a significant role in agriculture, food production, and environmental monitoring, among other fields. Additionally, it has provided valuable insights into evolutionary biology, cell biology, and the fundamental mechanisms of life. The Wikipedia page on microbiology provides detailed information about the history of the field, the different types of microorganisms, and the various scientific techniques used in microbiology. It also covers the applications of microbiology in medicine, industry, and environmental science. The page serves as a comprehensive resource for those interested in learning more about the fascinating world of microorganisms and their impact on our lives.

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